Although CMBs are a typical feature of CAA [23] and Aβ deposits and p-Tau proteins are typical pathological markers of degenerative diseases, especially Alzheimer’s disease [24], accumulating studies have elucidated that Aβ proteins, p-Tau proteins, and CSVD, which occasionally coexist, are the most common reason for cognitive impairment in the elderly [6]. The gene discussed is MAPT; the disease is Cognitive impairment.