In male individuals with obesity, ACTH measured in the post-CRH sample was higher than in male non-obesity controls (OB: 1.95 pmol/l vs. NO: 1.05 pmol/l, p = 0.024, Kruskal–Wallis test with Dunn’s multiple comparison correction, see Suppl. Here, CRH is linked to obesity due to melanocortin 4 receptor deficiency.