Individuals with obesity showed higher HPA axis responsiveness than their non-obese counterparts in the dex/CRH test with statistical significance for cortisol 30 min after stimulation with CRH (see Table 2 and Figure 1A,B), as well as a higher adrenal sensitivity to ACTH as measured by a lower ACTH/cortisol ratio (see Table 2). Here, CRH is linked to obesity due to melanocortin 4 receptor deficiency.