In general, as outlined in Figure 1 and Figure 2A, we observed robust tumor induction in a reliable manner [41,42], i.e., stable tumor formation and comparable median symptom-free survival, in two independently conducted experiments using the RCAS-tva system with a PDGFB overexpression in Cdkn2a deleted mice, underlining the high reproducibility of the model (Figure 3A). This evidence concerns the gene CDKN2A and neoplasm.