CRLS1 and Insulin resistance: For example, Tu et al. studied the role of CRLS1, which is involved in the first step of cardiolipin synthesis, and they discovered that CRLS1 is significantly downregulated in liver of mice fed an HFD or ob/ob mice and that liver-specific deletion of CRLS1 aggravates HFD-induced insulin resistance and hepatic steatosis [132].