MSLN and fibrosis: Analogous to the observations in the Mdr2−/− cholestatic fibrosis model, Msln−/−Thy1−/− mice with bleomycin-injured lung fibrosis or UUO-injured kidney fibrosis showed fibrotic phenotypes comparable with wild-type mice, supporting the consistency of opposing function of Msln and Thy1 in regulation of tissue fibroblasts activation [17].