CA125 is widely accepted as a diagnostic marker of ovarian cancer and a number of other malignant conditions such as breast cancer, mesothelioma, non-Hodgkin lymphoma, pancreatic cancer, gastric cancer, and leiomyoma [83], with exemption of benign conditions including endometriosis, pregnancy, congestive heart failure, nephrotic syndrome, and fibrosis-associated disease including liver cirrhosis and pulmonary fibrosis [84,85,86,87,88]. This evidence concerns the gene MUC16 and ovarian carcinoma.