TIMP1 and infection: Furthermore, in SSSIs requiring an improvement in wound healing, daptomycin has been shown to be effective both in eradicating the infection and in promoting skin healing through immunomodulatory effects, firstly by reducing local levels of interleukin (IL)-6 and matrix metalloproteinase (MMP)-9 and, secondly, by increasing metallopeptidase inhibitor (TIMP)-1, epidermal growth factor receptor (EGFR) and fibroblast growth factor (FGF)-2 [42,43].