TLR7 and systemic lupus erythematosus: In the present study, we have demonstrated that two miRNAs, miR-128 and miR-148a, are coordinately downregulated in pDCs in the IMQ-induced SLE mouse model and that downregulation of miR-128-3p and miR-148a-3p constitutes a feedback loop that enhances the TLR7-mediated inflammatory response by additively targeting KLF4 (Fig. 8G).