NLRP3 and infection: To clarify the role of LSD1 in OGD/R-induced pyroptosis of RGC-5 cells, we successfully suppressed LSD1 expression in RGC-5 cells through infection with shRNA-LSD1 lentivirus (sh-LSD1) (p < 0.05, Fig. 2A, B), and then discovered that protein levels of NLRP3, GSDMD-N, and cleaved-Caspase1 were decreased (p < 0.05, Fig. 2A), the mRNA levels of Caspase 1 were decreased (p < 0.05, Fig. 2B), and IL-1β and IL-18 concentrations were declined in OGD/R-treated RGC-5 cells (p < 0.05, Fig. 2C).