Regarding the molecular and cellular characteristics, compared with the G3 group, G2 and G4 groups had higher enrichment scores on tumor-related signaling pathways, including cell cycle, regulation of autophagy, mismatch repair, MTORC1 signaling, MYC-targets V2, unfolded protein response, nucleotide expression repair, PI3K/AKT/mTOR, reactive oxygen species pathway, but lower scores on B cell receptor pathway and p53 pathway. Here, AKT1 is linked to neoplasm.