Many UBE2T substrates have been reported, including p53 [7] and Mule [8] in hepatocellular carcinoma (HCC), BRCA1 in breast cancer [9], FOXO1 in lung cancer [10], and the receptor for activated protein kinase C (RACK1) in gastric cancer (GC) [11]. The gene discussed is HUWE1; the disease is hepatocellular carcinoma.