Age‐associated reductions in Bregs frequency, as well as impaired IL‐10 production, were observed in healthy older donors (> 60 years) compared to healthy younger donors (20‐40 years old) [41]. Patients that succumbed to shock might be due to B cells exhibited a decrease in IL-10 secretion, indicating that both anti-inflammatory cytokines, inhibition of B cells in the initial stage of sepsis in elderly patients, and exogenous IL-10 had protective effects in sepsis. The gene discussed is IL10; the disease is Sepsis.