Comparing the expression levels of 76 NRGs in TCGA samples, several NRGs (ATRX, AXL, BACH2, BCL2, BRAF, CFLAR, KLF9, NDRG2, NR2C2, SIRT1, SIRT3, TLR4, TSC1, USP22) were found at lower expression levels in four gynecological tumors (Fig. 1A), and several NRGs (CDKN2A, CXCL1, DIABLO, EZH2, GATA3, HSPA4, IDH2, PGAM5, PLK1, TERT, TNF, and TNFRSF21) were found at higher expression levels in four gynecological tumors (Fig. 1A). The gene discussed is TLR4; the disease is female reproductive system neoplasm.