However, deeper definition of the epitranscriptomic changes in other non-coding and coding RNAs as well as further characterization of alterations in other epitranscriptome regulatory proteins in AD such as Mettl3, HNRNPA2B1, YTHDF3 or YTHDF3 are needed (Supplementary Fig. 4, online resource) [33, 36, 42, 98]. Here, METTL3 is linked to Alzheimer disease.