Causal genes for these GIMs included established genes for CAD (for example, PCSK9, SORT1 and LDLR), age-related macular degeneration (LIPC and APOE/APOC[1,2,4]), Crohn’s disease (GCKR and FADS2) and CKD (GATM). This evidence concerns the gene APOE and age-related macular degeneration.