DBH and hypertensive disorder: We identified associations of a missense variant in DBH (rs6271, p.R549C, MAF = 7.45%) with lower levels of the norepinephrine catabolite vanillylmandelate (β per minor (T) allele = −0.164, P = 8.00 × 10−13), as well as lower systolic and diastolic blood pressure and lower risk of hypertension in independent, non-overlapping studies35–38.