The observations that genetic variants associated with homoarginine are probably linked to transporters with specific affinity to homoarginine (SLC15A19 and SLC7A7) and that the known CKD intergenic variant rs1145091 (near GATM) was the strongest variant for plasma homoarginine levels argue for a possible distinct role of plasma homoarginine compared to arginine-related metabolites in plasma in CKD pathology. This evidence concerns the gene SLC7A7 and chronic kidney disease.