PTGDS and neoplasm: Compared to fibroblasts from normal tissues, the top upregulated genes in tumor-derived fibroblasts were CXCL8, CXCL2, CCL2, CXCL3 and CXCL1, and the top downregulated genes were IGFBP5, PTGDS, CCN5, CFD, and RAMP1 (Fig. 3d, Supplementary Data 2).