ROC curves analysis depicted that VEGF-A (Youden index-based cut off 95.77 pg/mL, sensitivity 87.5%, and specificity 95%), TNF-α (Youden index-based cut off 28.37 pg/mL, sensitivity 87.5%, and specificity 80.0%), CCL2 (Youden index-based cut off 462.3 pg/mL, sensitivity 87.5%, and specificity 75.0%), IL-6 (Youden index-based cut off 2.195 pg/mL, sensitivity 100%, and specificity 75%) and IFN-γ (Youden index-based cut off 0.6410 pg/mL, sensitivity 87.5%, and specificity 90%) illuminated an excellent value in identifying cancer among the anti-TIF1-γ antibody-positive DM patients. Here, IFNG is linked to cancer.