For instance, Allen et al. combined anti-VEGFR2 antibody and anti-PD-L1 antibody in several tumor mouse models and found the antiangiogenic therapy can sensitize tumors to ICIs therapy specifically by generating intratumoral high endothelial venules (HEVs) that facilitate enhanced T cells infiltration, activity, and tumor cell destruction [25]. Here, KDR is linked to neoplasm.