Eleven druggable genes (WNK3, HSP90AA1, CA3, CAST, PFKFB4, SLC7A7, HDAC3, HSP90B1, SIK3, CTRL, and OSGEPL1) and two cancer drivers (SMAD4 and PAN3) were finally identified and validated to enhance PD-L1 expression. Here, SMAD4 is linked to cancer.