CD4 and neoplasm: Importantly, flow cytometry analysis of the tumors obtained after WNK463 therapy (Fig. 5f, left) revealed a dose-dependent decrease in PD-L1 levels in neoplastic cell populations (Fig. 5i) but an increase in IFN-γ and TNF-α produced by CD4+ and CD8+ T cells in tumor-infiltrating lymphocytes (Fig. 5j).