To elucidate the signaling pathways involved in WNK3-mediated PD-L1 regulation, we investigated several key signaling pathways, including JNK/c-JUN, ERK, p38, AKT, NF-κB, and JAK/STAT, which regulate PD-L1 transcription in cancer cells30. This evidence concerns the gene NFKB1 and cancer.