The odds of having a carotid plaque were 0.09 times lower (95% CI 0.008, 0.98, p < 0.05) among those APOE e4e4 participants who presented High-CRF (VO2max > 35 mL/kg/min) than those APOE e4e4 participants allocated to the Low-CRF group (VO2max ≤ 35 mL/kg/min) after adjusting for age, BMI, hypertension, dyslipidemia, diabetes, smoking status, MVPA, and aMED score (Table 3). The gene discussed is APOE; the disease is metabolic syndrome.