The odds of showing a carotid plaque were 4.29 times higher (95% CI 1.16, 15.91, p < 0.05) among those participants genotyped as APOE e4e4 than those genotyped as APOE e3e3 after adjusting for BMI, hypertension, dyslipidemia, diabetes, MVPA, VO2max, and aMED score (Table 2). The gene discussed is APOE; the disease is metabolic syndrome.