However, a secondary analysis showed a linear trend with increasing odds of carotid plaque per unit change in genotype among APOE e3e4 and APOE e4e4 participants in relation with those APOE e3e3 participants, (ORs 1.92; 95% CI 1.07, 3.44, p = 0.03) after adjusting the results for BMI, hypertension, dyslipidemia, diabetes, MVPA, VO2max, and aMED score. Here, APOE is linked to metabolic syndrome.