The odds of having a carotid plaque were 0.003 times lower (95% CI: 0.0001, 0.89, p < 0.05) among those APOE e4e4 participants who presented High-CRF (VO2max > 34.3 mL/kg/min) than those APOE e4e4 participants who presented Low-CRF (VO2max ≤ 34.3 mL/kg/min) after adjusting for age, BMI, hypertension, dyslipidemia, diabetes, smoking status, MVPA, and aMED score (Table 4). The gene discussed is APOE; the disease is Hypertension.