Our findings demonstrate that as %BF increases there is a decreased efficacy of SARS-CoV-2 mRNA vaccination, characterized as decreased S1, S2, and RBD antibodies present in the serum, which can lead to a greater risk of contracting SARS-CoV-2 and developing COVID-19 regardless of the individual’s age, type of mRNA vaccine received, and time since vaccination. The gene discussed is PSMD1; the disease is COVID-19.