OTUD1 and Miyoshi myopathy: To further study the involvement of OTUD1 in Ig production, we generated a panel of MM cell lines with doxycycline (dox)-inducible OTUD1 overexpression (OTUD1 oe) and shRNA-mediated OTUD1 knock-down (sh OTUD1_1, sh OTUD1_2) (Fig. 2a–c).