In order to further characterize potential functional redundancy of TFEB and TFE3 in the TSC2 KO background, we performed RNA-seq on tumor xenografts grown from WT, TSC2 KO, and TFEB KO, TFE3 KO and double TFEB/TFE3 KO cells (Fig. 4d). This evidence concerns the gene TFE3 and neoplasm.