TFEB hypophosphorylation was additionally observed in vivo in TSC2 KO tumor xenografts (Fig. 5d), Tsc2-deficient, TTJ-parental cells (Fig. S7c), and TSC2-deficient human TRI-102 cells (an E6/E7 and hTERT- immortalized derivative of human TSC2-null, primary renal angiomyolipoma cells44,) (Fig. S7d), compared to their TSC2/ Tsc2 expressing, wild-type counterparts, respectively. This evidence concerns the gene TSC2 and neoplasm.