In contrast, torin did not significantly affect tumor growth (Fig. 2k), consistent with the lack of effect on TFEB nuclear localization, despite suppressed phosphorylation of classic mTORC1 substrates (p-4E-BP1 and p-p70S6K) in TSC2 KO tumor lysates (Fig. 2l and Fig. S3a, b). This evidence concerns the gene EIF4EBP1 and neoplasm.