To investigate possible skeletal muscular APPswe’s effect in AD and sarcopenia development, we generated TgAPPsweHSA or LSL-APPswe:HSA-Cre mice by crossing LSL(Loxp-Stop-Loxp)-hAPPswe (human APPswe) with HSA-Cre (human skeletal a-actin promoter driven Cre) mice (Fig. S1A). Here, ALB is linked to sarcopenia.