THY1 and Alzheimer disease: Although APPswe is detected in small fractions of EOAD patients, its functions in Aβ production in the brain and in promoting AD pathogenesis have been well studied in multiple animal models (e.g., Tg2576 and 5XFAD, both well-characterized AD animal models that express APPswe under the control of prion and Thy1 promoter, respectively).