SMCR8 and Smith-Magenis syndrome: In another example, Smith-Magenis Syndrome Chromosomal Region Candidate Gene 8 (SMCR8) forms the heterotrimer C9orf72-SMCR8-WDR41 complex (3 protein members in CORUM) together with the C9orf72-SMCR8 Complex Subunit (C9orf72) and WD Repeat Domain 41 (WDR41) [48].