ANO1 and pulmonary arterial hypertension: In the future, because TMEM16A participates in the myogenic tone of cerebral artery [55] and in pericyte contraction [56], it could become a target in small vessel disease, stroke or vascular dementia and also in systemic or pulmonary hypertension by controlling vasoconstriction [57,58] or the vascular remodeling [18,19,59].