It was shown that components of Clonorchis sinensis excretory-secretory products, such as secretory phospholipase A(2), fructose-1, 6-bisphosphatase, lysophospholipase, and Fe heavy chain protein, directly activated human HSCs and other key cells in hepatic fibrosis process [46]. The gene discussed is FBP1; the disease is Hepatic fibrosis.