TNF and cancer: The species in the network in Fig 1 include cancer cells (C), CD8+ T cells (T8), CD4+ T cells (Th1 (T1) and Tregs (Tr)), dendritic cells (D), and cytokines IL-2 (I2), IL-12 (I12), TGF-β (Tβ) and TNF-α (Tα).