We want to determine by the end of the first 3 cycles (day 70) in which anti-CTLA-4 is administered, when is the optimal time to start treatment with prednisone in order to keep toxicity as small as possible, while still decreasing tumor growth, and hopefully also keep volume as small as possible by the end-time of prednisone treatment, which we take to be day 126. The gene discussed is CTLA4; the disease is neoplasm.