We simulated the outcome of each schedule up to day 126, and computed two quantities:Tα,ave(70,Si)=AverageofTα-Tα,conatday70,V(70,Si),V(126,Si)=Volumeoftumoratdays70,126,where Tα,con is the average concentration of TNF-α in the control case (no drugs) when we know that hypophysitis does not occur; Tα,con(t) is approximately 6.76 pg/cm3. This evidence concerns the gene TNF and hypophysitis.