In addition, we correlated the gut microbiota of pSS patients with candidate biomarkers, including autoantibodies (antinuclear [ANA], anti-Ro52, anti-Ro/SSA, and anti-La/SSB) [14], rheumatoid factor (RF), C-reactive protein (CRP), immunoglobulins (Ig: IgG, IgA, IgM, and IgE), and complement components 3 (C3) and 4 (C4). This evidence concerns the gene CALR and peeling skin syndrome.