For both models, 7 days after the induction of colitis, elafin‐expressing mice were protected from colitis, showing a decreased infiltration of inflammatory cells, decreased tissue damage, inhibition of pro‐inflammatory cytokines such as IL‐6 and IL‐17 or chemokines such as KC (the mouse homlogue of CXCL1), CCL3 (MIP‐1α), CXCL2 (MIP‐2), and CCL5 (RANTES) (Motta et al., 2011). Here, PI3 is linked to colitis.