ESR1 and colorectal carcinoma: Solid Tumors: Estrogen receptors (ER) may contribute to the pathogenesis of colorectal carcinoma (CRC) with support of ER pathway targeting by pterostilbene (Pter, a component in blueberries and analog of resveratrol); via molecular docking simulations, Pter was identified to dock into the ER-β active site with high affinity, similar to 17-β-estradiol [153].