In Caco-2 human intestinal cancer cells, CuE (1 μM) induced apoptosis; this cellular outcome was accompanied not only by increased ER stress markers (i.e., CHOP and GRP78) and autophagy markers (i.e., LC3B-II and Beclin-1), but reduced p-mTOR and p-AKT (along with reducing total AKT) proteins were also reported [97]. This evidence concerns the gene AKT1 and intestinal cancer.