Fractions with the highest concentration of proanthocyanidin (PAC) inhibited cellular viability and reduced tumor volumes while also reducing p-JAK1, p-JAK2, p-JAK3, p-STAT1, p-STAT3, and p-STAT5 (although there was no change in total STATs, total JAKs were decreased) [138]. The gene discussed is JAK2; the disease is neoplasm.