Blood Cancers: One component from the Jewel black raspberry extract, namely cyanidin-3-rutinoside (C3R, 50 μM), reduced cellular viability via induction of apoptosis in leukemic HL-60 cells; these cellular outcomes were associated with elevated p-p38 and p-JNK levels [218]. Here, MAPK8 is linked to hematopoietic and lymphoid system neoplasm.