AKT1 and prostate carcinoma: In addition, proanthocyanidin-enriched extracts from cranberries (CPAC, 25 μg/mL) reduced cellular viability in DU145 prostate cancer cells that were associated with alterations in signaling pathways, including reduced p-AKT (and total AKT, however) with increased p-p38 and p-ERK1/2 [126].