STAT3 and cancer: Solid Tumors: Although CuQ (0.5–1 mg/kg) inhibited tumor growth most effectively using A549 cells in a mouse xenograft model along with reduced p-STAT3 levels in a series of cancer cell lines, CuQ (10 μM) did not elicit a change in p-JAK2 (with contrasts with responses to CuA, CuB, CuE, and CuI) [117].