AKT1 and breast carcinoma: Red-flesh (AFP) or peel (APP, phenolic content is higher) component of apples (Meihong variety) was tested on breast cancer cell lines (250–1000 μg/mL); it was identified that the APP was more potent in mediating reduction in cellular viability along with G0/G1 phase arrest and apoptotic response; these functional changes were associated with reduced p-AKT and p-BAD [171].