MAPK1 and hereditary pheochromocytoma-paraganglioma: In this regard, H2O2-stimulated pheochromocytoma PC-12 cells treated with TFs (100–500 μg/mL) recovered cell health in addition to the reduction in pro-inflammatory cytokine production (i.e., IL-1, IL-6, and TNFα) and reduction in p-ERK, p-JNK, and p-p38 levels [205].