AKT1 and cancer: Solid Tumors: In an array of cancer cell lines, a compound isolated from Potentilla discolor Bunge, namely PDB-1 (C-27-carboxylated-lupane-triterpenoid derivative), was found to reduce cellular viability (most potent at IC50 of 7.8 μM in A549) along with induction of G2/M phase arrest; these cellular outcomes were associated with reduced p-PI3K, p-mTOR, and p-AKT levels [215].