TNF and Alzheimer disease: With respect to Alzheimer’s disease (AD), blueberry supplementation (BB, 25–100 μg/mL) fed to mutant amyloid precursor protein/presenillin 1 mice were normal in terms of their Y-maze performance at 12 months of age along with normal amyloid beta burden; furthermore, in primary microglial cells stimulated with LPS, BB (5 μM) reduced pro-inflammatory cytokines (i.e., TNFα and IL-6) and reduced p-p42/44 MAPK proteins [152].