Further study showed that quercetin enhanced the nuclear translocation of transcription factor EB (TFEB) protein, upregulating the expression of lysosomal-associated membrane protein 1 (LAMP-1) in breast cancer cell lines, which in turn promoted ferritin degradation and the release of ferric ions, triggering the onset of iron death in these breast cancer cells. The gene discussed is TFEB; the disease is breast carcinoma.