ENO2 and cancer: Figure 6 and Supplementary Table S10 show that RG–RS strongly downregulates the expression of five genes upregulated in cancer cells: 2562-fold downregulated neuron-specific enolase (NSE) ENO1 gene, 1426-fold downregulated phosphoglycerate kinase 1 PGK1 gene, 1094-fold downregulated pyruvate kinase PKM gene, 855-fold downregulated aldolase ALDOA gene, and 810-fold downregulated triose phosphate isomerase TPI gene.