HCC-targeted antibodies labeled with 131I have been intensively studied for the treatment of HCC, with the most common antibodies including mouse anti-human monoclonal antibody fragment HAb18F(ab)2 (metuximab), ChTNT human-mouse chimeric antibody, hepama-1 HCC cell membrane monoclonal antibody, CD133 monoclonal antibody, anti-hepatitis B virus antibodies, anti-machine protein monoclonal antibody, and anti-human HCC transferrin monoclonal antibody. This evidence concerns the gene PROM1 and hepatocellular carcinoma.