Additionally, this EVOO-related secoiridoid has been shown to inhibit lysine-specific histone demethylase 1A (LSD1) also known as lysine (K)-specific demethylase 1A (KDM1A) a central epigenetic regulator of metabolic reprogramming in obesity-associated diseases, neurological disorders, and cancer [51]. Here, KDM1A is linked to obesity due to melanocortin 4 receptor deficiency.