The GO and KEGG pathway analysis of DEGs showed fascinating results, including the activation of expected matrix-related “ECM-receptor interaction” and “Focal adhesion”, immune-related “Th1 and Th2 cell differentiation” and “B cell receptor signaling pathway” and PI3K/Akt signaling pathways, suggesting that these DEGs affect the prognosis of PAAD by the possible means of activating these pathways, thereby regulating malignant biological behaviors such as proliferation, invasion, and metastasis of tumor cells. This evidence concerns the gene AKT1 and pancreatic adenocarcinoma.