Our results found that in samples with higher risk scores, immune function “MHC class I” were up-regulated and “T cell co-stimulation” were down-regulated, and there were fewer CD8+T cells in the immune cell population, which may indicate that as the risk factor increases, CD8+T cells fail to activate and are in an incompetent state, or even undergo apoptosis to effectively fight tumor formation and progression due to the persistent driving effect of long-term antigen presentation and the lack of costimulatory signals provided by T-cell co-stimulation molecules. This evidence concerns the gene CD8A and neoplasm.