In an Aβ25-35-induced rat model of AD, ASPs improved spatial learning and memory impairment, regulated the balance of neurotransmitters, inhibited the expression of proinflammatory cytokines, including TNF-α, IL-1β, and TNF-α, inhibited the activity of SOD and catalase (CAT), decreased MDA activity, and inhibited the expression of caspase-3 and the ratio of Bax/Bcl-2. The gene discussed is TNF; the disease is Alzheimer disease.