TNFRSF11A and periodontitis: As reported by Zhong et al., 2020 [5], based on an experimental periodontitis induction in rats through the ligation method, CuB treatments (12.5 mg, 25 mg, and 50 mg kg−1 body weight) for 12 days showed a significant decrease in alveolar bone loss through the regulation of RANK/OPG levels, as well as the reduction of inflammatory responses in periodontitis in a preclinical trial.