EGFR and familial pancreatic carcinoma: In this context, it has been found that CuB inhibits the epidermal growth factor receptor (EGFR), prevents the growth of pancreatic cancer cells, and produces apoptosis through the negative regulation of anti-apoptotic proteins such as Bcl-2 and the increase in the amount of the proapoptotic protein Bim [44] (Figure 3A).