Liang et al., 2021 [118], described the antiproliferative activity of CuIIb in A549 lung cancer cell lines through the STAT3 pathway that is modulated by the mitochondria and is caspase-dependent, in conjunction with an alteration of cellular activity in the G2/M phase, which is also attributed to the ability to intervene in the signaling of the mitogen-activated protein kinase/EGFR (MAPK) pathway. This evidence concerns the gene STAT3 and lung carcinoma.