The results showed that the administration of CuE inhibited the production of inflammatory cytokines induced by LPS, such as TNF-α, IL-6, and IL-8, by inhibiting the activation of HMGB1, TLR4, and p-p65 NF-κB, as well as reducing the release of mucin 5AC (MUC5AC); therefore, CuE could be considered a promising agent in asthma therapy. The gene discussed is MUC5AC; the disease is asthma.