Accordingly, functional interrelationships related to mesocortical and mesolimbic pathways of A2A/D2 receptor interactions that are impaired by ethanol administrations may result in emotional, motivational, rewarding, and addiction behavior disruption and learning dysfunction, which reinforces the putative role of the adenosine modulation system in several neuropathologies, such as anxiety, drug addiction, schizophrenia, and depression [71,122]. The gene discussed is IGKV2D-29; the disease is depressive disorder.