IGKV2D-29 and alcohol abuse: Reward circuitry activation by glutamatergic inputs from the cortex, as well as dopaminergic inputs from the ventral tegmental area with projections to medium spiny neuron striatum, through heterodimers of A2A-D2 and A2A-mGlu5 receptors, may be probable pathophysiological mechanisms induced by ethanol abuse since this substance increases adenosine levels causing hyperactivation of A2AR, with consequent increased release of dopamine and glutamate [32,86,87].