It is well-defined that elevation of CREB expression in the dorsomedial striatum, olfactory bulb, and GABAergic neurons of caudate-putamen, nucleus accumbens, and tuberculum olfactory, also occurs upon recruitment of A2AR and is likely associated with negative behavioral changes (i.e., anxiety-like and depressive-like phenotype) induced by heavy ethanol consumption in mice [71,119]. Here, ADORA2A is linked to Anxiety.