A hit compound with a benzo[a]dihydrocarbazole structure turned out to be the most interesting one and was assayed on three different glioblastoma multiforme (GBM) cell lines (U343MG, U87MG, and T98G) to prove its activity on p53–MDM2 complex, its ability to restore p53 function, and its capability to reduce the GBM cell growth. Here, TP53 is linked to glioblastoma.