STK11 and neoplasm: ASC lesions have been reported to be more aggressive and have a poor prognosis when compared to AC tumors (Nagaraj et al., 2017; Pan et al., 2018), and molecular mechanisms underpinning the differential colonization/ metastatic capacity of tumor cells harboring equivalent genetic driver mutations (KrasG12D/+;Lkb1−/−) but different histopathology are intriguing.