Notably, depletion of tNASP reportedly inhibits proliferation in prostate cancer PC-3 cells and renal cell carcinoma cells (Alekseev et al., 2011; Fang et al., 2015), echoing the cell cycle defects of Srsf10-cKO spermatogonia. This evidence concerns the gene SRSF10 and hereditary clear cell renal cell carcinoma.