IL2 and peeling skin syndrome: As a hallmark feature of pSS, B cell hyperactivity results in hypergammaglobulinemia, autoantibody production, and increased risk of B cell lymphomas, especially B cell–derived non-Hodgkin lymphomas.6,7 These pathogenic B cell responses are initiated and reinforced by autoreactive effector T cells.8,9,10 Impairment of Treg cell function has been reported in patients with pSS, and it can be improved by LD-IL-2.11 It is possible that targeted therapies to pathogenic B and T cells may have potential significance in pSS.