IL2 and peeling skin syndrome: However, no statistical significance was achieved in these changes, which may be due to the irreversible damages in salivary and lacrimal glands of the long disease duration.40 Fatigue is a common clinical feature of pSS.1 This study showed that LD-IL-2 significantly alleviated this symptom, associated with reductions of IL-17 and IFN-α, which could contribute to the amelioration of fatigue (eFigure 5 in Supplement 2).