PKM and obesity due to melanocortin 4 receptor deficiency: In this study, proteins related to glycolytic, carbohydrate catabolic, glucose metabolic, organophosphate metabolic, and carbohydrate derivative metabolic processes (such as 6-phosphogluconate dehydrogenase, Decarboxylating; Pyruvate kinase PKM; Glyceraldehyde-3-phosphate dehydrogenase; Transaldolase; Fructose-bisphosphate aldolase A; Phosphoglycerate kinase 2; and Glucose-6-phosphate isomerase) were more expressed in individuals with obesity (Figure 5).