In this study, the CA-VI levels were decreased in individuals with obesity (OP and OWP) when compared to their controls (NP and NWP, respectively), while Zinc-α-2 glycoprotein was positively associated with obesity when we compared OP versus NP since it was a specific protein found only in OP; however, there was no intergroup difference when OWP was compared to NWP. The gene discussed is CA6; the disease is obesity due to melanocortin 4 receptor deficiency.