TNF and obesity due to melanocortin 4 receptor deficiency: The same mechanism may be observed in individuals with obesity since their adipose tissue secretes inflammatory cytokines and adipokines, such as Tumor Necrosis Factor alpha (TNF-α), IL-6, adiponectin, leptin, adipocytokine, and cytoplasmic enzymes [2], which reduce the host’s immune response and cause a generalized inflammatory state of the body, including the periodontium [3].