The NP analysis revealed that metabolites from plasma, urine, and feces could be responsible for the pharmacological activity of thrombocytopenia by regulating the following pathways in cancer: PI3K-Akt, MAPK, JAK-STAT, VEGF, chemokine, actin cytoskeleton, HIF-1, and pluripotency of stem cells. Here, HIF1A is linked to Thrombocytopenia.