1960 HeFH patients vs. 957 non-FH relatives: 23.6 (9.6–59.2) vs. 21.0 (7–47.2) mg/dL, p < 0.001. 500 FH patients with null mutations vs. 246 FH patients with defect LDLR mutations: 24.4 vs. 21.5 mg/dL, p < 0.05. The gene discussed is LDLR; the disease is familial hyperaldosteronism.