Besides this, the KYNU upregulation due to the constitutive activation of the redox regulator, the nuclear factor erythroid 2-related factor (Nrf2) was associated with immunosuppressive phenotypes and a lower survival of lung adenocarcinoma patients [62], while the KYNU knockdown decreased the malignant cell proliferation and migration through the downregulation of PI3K/AKT signaling on cutaneous squamous cell carcinoma [63]. This evidence concerns the gene NFE2L2 and cutaneous squamous cell carcinoma.