Artificial intelligence, biotechnology, and nanoengineering are potential devices to design innovative peptide materials that could be used to design new drugs with a broad cellular penetration power to silencing KP enzymes; an excellent option could be cell-penetrating peptide amphiphiles, molecules with a capacity to form complexes with siRNAs, as an alternative for therapeutic delivery in glioma cells [67]. Here, NPPA is linked to central nervous system cancer.