In the present study, to determine the role of Sg on postprandial hyperglycemia in obese/overweight, the associations between SgIo and 1,5-anhydroglycitol (AG), a clinical index of postprandial hyperglycemia, were examined with the adjustment of disposition index, a measure for insulin secretion relative to insulin sensitivity. The gene discussed is INS; the disease is Hyperglycemia.