Following identification of the key pathway (HIF-1 signaling route) within the network for progression of T2DM disease, of the 14 associated targets in this hub, the EGFR and IGF1R were identified as the hub targets (10- and 5-degree values, respectively) in the HIF-1 key pathway (Table 2, Figure 5). Here, IGF1R is linked to type 2 diabetes mellitus.