PIK3R1 and diabetes mellitus: Given the metabolomic results showing riboflavin metabolism as the main pathway of GRb1 action in diabetes, we performed molecular docking analysis by Sybyl-x 2.1 to further evaluate the binding pattern of GRb1 with the upstream and downstream proteins SLC52A1, SLC52A2, SLC52A3, and RFK of riboflavin.