CD274 and neoplasm: Since 786-O cells can form large tumor spheroids with diameters reaching up to one millimeter, the ability of PD1EcTMDAP10IC+ and PD1EcTMDAP12IC+ NK-92 cells to kill PD-L1+ 786-O WT cells was tested in the 3D co-culture model as it more accurately resembles the TME than a 2D co-culture model.