Promisingly, our preclinical data show that both PD1EcTMDAP10IC+ and PD1EcTMDAP12IC+ pNK cells from newly diagnosed MM patients increase degranulation and cytokine production against autologous PD-L1+ CD138+ BM MNC while sparing PD-L1− CD138− samples. The gene discussed is SDC1; the disease is Miyoshi myopathy.