DDR1 and neoplasm: As a non-canonical collagen receptor, Ddr may also interact with other collagen receptors, such as integrins (known to play roles in wrapping glia development; Xie and Auld, 2011), to sense and remodel the extracellular matrix and permit extension of glia processes between axons, similar to its roles in promoting tumor metastasis (Itoh, 2018).